https://nova.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:34320 Wed 19 Jan 2022 15:15:22 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:36223 Wed 11 Mar 2020 11:08:42 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:19230 Wed 11 Apr 2018 14:36:46 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:28469 Wed 11 Apr 2018 10:47:35 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:24126 in vivo use.]]> Wed 09 Mar 2022 15:58:21 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:34765 1H, ¹³C, ¹¹⁹Sn) NMR and mass spectrometry, and single crystal X-ray diffraction. The organotin(IV) compounds were synthesised from the reaction of Ph₂SnCl₂ or Me₂SnCl₂ with the Schiff bases (S2MoVaH/S4MoVaH/SBoVaH) to form a total of six new organotin(IV) compounds that had a general formula of [R2Sn(L)] (where L = Schiff base; R = Ph or Me). The molecular geometries of Me₂Sn(S2MoVa), Me₂Sn(S4MoVa) and Me₂Sn(SBoVa) were established by X-ray crystallography and verified using density functional theory calculations. Interestingly, each experimental structure contained two independent but chemically similar molecules in the crystallographic asymmetric unit. The coordination geometry for each molecule was defined by thiolate-sulphur, phenoxide-oxygen and imine-nitrogen atoms derived from a dinegative, tridentate dithiocarbazate ligand with the remaining positions occupied by the methyl-carbon atoms of the organo groups. In each case, the resulting five-coordinate C2NOS geometry was almost exactly intermediate between ideal trigonal-bipyramidal and square-pyramidal geometries. The cytotoxic activities of the Schiff bases and organotin(IV) compounds were investigated against EJ-28 and RT-112 (bladder), HT29 (colon), U87 and SJ-G2 (glioblastoma), MCF-7 (breast) A2780 (ovarian), H460 (lung), A431 (skin), DU145 (prostate), BE2-C (neuroblastoma) and MIA (pancreatic) cancer cell lines and one normal breast cell line (MCF-10A). Diphenyltin(IV) compounds exhibited greater potency than either the Schiff bases or the respective dimethyltin(IV) compounds. Mechanistic studies on the action of these compounds against bladder cancer cells revealed that they induced the production of reactive oxygen species (ROS). The bladder cancer cells were apoptotic after 24 h post-treatment with the diphenyltin(IV) compounds. The interactions of the organotin(IV) compounds with calf thymus DNA (CT-DNA) were experimentally explored using UV-vis absorption spectroscopy. This study revealed that the organotin(IV) compounds have strong DNA binding affinity, verified via molecular docking simulations, which suggests that these organotin(IV) compounds interact with DNA via groove-binding interactions.]]> Wed 09 Feb 2022 15:52:49 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:48151 Wed 08 Mar 2023 14:43:43 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:40844 Tue 19 Jul 2022 11:15:16 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:39144 1H NMR, ¹³C NMR, ³¹P NMR, ¹⁹F NMR, and ¹¹B NMR) and 2D NMR (COSY, HSQC, and HMBC) analyses, high-resolution mass spectrometry, and chemical tests (primarily the silver nitrate test). Preliminary thermal analysis tests by thermogravimetric analysis show all novel RTILs display remarkably high thermal stabilities (386–474 °C). Differential scanning calorimetry data show low glass transitions ranging from −36 to −72 °C, which suggests good free volume and ion mobility.]]> Tue 17 May 2022 14:12:41 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:46316 1, inhibits hexokinase, suggesting that it will be phosphorylated in the cell. A Co(III) complex incorporating this ligand and coumarin-343 hydroximate (C343ha), [Co(C343ha){tpa(CONHPEGglucose)₁}]Cl, is shown to exhibit glucose-dependent cellular accumulation in DLD-1 colon cancer cells. Cellular accumulation of [Co(C343ha){tpa(CONHPEGglucose)₁}]⁺ is slower than for the glucose null and glucosamine analogues, and the glucose complex also exhibits a lower ability to inhibit antiproliferative activity. Distributions of cobalt (X-ray fluorescence) and C343ha (visible light fluorescence) in DLD-1 cancer cell spheroids are consistent with uptake of [Co(C343ha){tpa(CONHPEGglucose)₁}]⁺ by rapidly dividing cells, followed by release and efflux of C343ha and trapping of the Co{tpa(CONHPEGglucose)₁} moiety. The Co{tpa(CONHPEGglucose)₁} moiety is shown to have potential for the caged and targeted delivery of highly toxic anticancer agents.]]> Tue 15 Nov 2022 11:39:06 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:41387 Tue 02 Aug 2022 17:40:34 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:41388 Tue 02 Aug 2022 17:40:26 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:36359 Thu 28 Oct 2021 13:03:11 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:52765 Thu 26 Oct 2023 14:39:03 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:33539 Thu 15 Nov 2018 15:26:24 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:33542 Thu 15 Nov 2018 15:26:23 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:18198 Sat 24 Mar 2018 08:04:50 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:19846 Sat 24 Mar 2018 07:57:06 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:30695 15H₁₀BN₂O₆) is formed under crystallization conditions from the 5-nitrosalicylate ester of 2-aminophenylboronic acid. The boron at the center of this structure exists as a tetrahedral complex produced by a dative bond with the amide carbonyl. The perpendicular shape produces an unusual packing structure including a bifurcated hydrogen bond between the amide hydrogen and carbonyl groups on two neighboring molecules. We propose that this reaction occurs due to increased Lewis acidity of the nitrosalicylate ester of 2-aminophenylboronic acid.]]> Sat 24 Mar 2018 07:35:07 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:26323 NAr coupling with 1-fluoro-4-nitrobenzene. Microwave coupling of 4-morphilinoaniline 8 and 4-(piperazine-1-yl)aniline 9 with 2-(2,5-dichloropyrimidine-4-ylamino)-N-methylbenzamide 10, proved to be the most efficacious route to the target analogues 6 and 7. This hybrid methodology reduced the number of synthetic steps, gave enhanced overall yields and increased atom economy through step reduction and minimal requirement for chromatographic purification, relative to the original batch synthesis approach.]]> Sat 24 Mar 2018 07:24:11 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:37093 Mon 17 Aug 2020 12:34:44 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:44154 2Sn(Lⁿ)] and [Sn(Lⁿ)₂] (where R = Ph or Me; Lⁿ = 1, 2, 3 and 4) were synthesized and characterized by elemental analysis, IR, UV–vis, mass spectrometry and multinuclear NMR (¹H, ¹³C and ¹¹⁹Sn) spectroscopy. X-ray crystallographic data was obtained for 11′, a 2:1 co-crystal between Ph₂Sn(L²) (11) and 3-methoxysalicylaldehyde azine, and Me₂Sn(L²) (12) where L²H₂ is 2-(2-hydroxy-3-methoxybenzylidene)-N-phenylhydrazinecarbothioamide. The analysis revealed distinct coordination geometries for 11 and 12 approaching trigonal–bipyramidal. In the crystal of 11′, supramolecular dimers arising from aminesingle bondNsingle bondH…S(thiolate) hydrogen bonding and {…HNCS}₂ synthons are evident; π(chelate ring)…π(oxidobenzylidene) stacking is also apparent. In the crystal of 12, supramolecular, helical chains are generated by a combination of aminesingle bondNsingle bondH…O(phenoxide) hydrogen bonding and Sn…S secondary bonding. The cytotoxic activity of the compounds against a panel of ten cancer cell lines, [HT29 (colon), U87 and SJ-G2 (glioblastoma), MCF-7 (breast), A2780 (ovarian), H460 (lung), A431 (skin), DU145 (prostate), BE2-C (neuroblastoma) and MIA (pancreas), and one normal cell line, MCF-10A (normal breast)] were investigated. The thiosemicarbazone Schiff bases 1 and 4 as well as the diphenyltin(IV) compounds showed a strong ability to inhibit the growth of cancer cells, with particular selectivity against HT29, MCF-7, A2780, A431, BE2-C, SJ-G2 and MIA cell lines. The structure–activity relationship of all these compounds were studied by evaluating the effect of alkyl and aryl groups attached on the thiosemicarbazone backbone, the methoxy/hydroxyl groups present at the meta-position of the phenyl ring and alkyl or aryl groups bound to the tin center.]]> Mon 10 Oct 2022 09:31:33 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:39057 Fsp³ index natural-product analogues such as imino­sugars are of paramount importance in the investigation of their biological activities and reducing the use of protecting groups is an advantageous synthetic strategy. An iso­propyl­idene group was employed towards the synthesis of seven-membered ring imino­sugars and the title compound, C₉H₁₅N₃O₅, was crystallized as an inter­mediate, in which the THF ring is twisted and the dioxolane ring adopts an envelope conformation: the dihedral angle between the rings is 67.50 (13)°. In the crystal, the hydroxyl groups participate in O—H...(O,O) and O—H...N hydrogen-bonding inter­actions, which generate chains of mol­ecules propagating parallel to the a-axis direction. There is a notable non-classical C—H...O hydrogen bond, which cross-links the [100] chains into (001) sheets.]]> Mon 02 May 2022 15:27:38 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:51500 Fri 08 Sep 2023 11:56:25 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:44102 Fri 07 Oct 2022 13:51:41 AEDT ]]>